Trk Receptor Inhibitors

TrkA

TrkB

TrkC

TrkB

TrkB

TrkA

TrkA, IC₅₀: 5 nM

TrkB, IC₅₀: 9 nM

TrkA

TrkB

TrkA, IC₅₀: 2 nM

TrkA, IC₅₀: 11 nM

TrkB, IC₅₀: 9 nM

TrkC, IC₅₀: 7 nM

TrkB

TrkA, IC₅₀: 25 nM

TrkA, IC₅₀: 0.6 nM

TrkC, IC₅₀: <2.5 nM

TrkA

TrkB

TrkC

TrkB

TrkC

Trk1, IC₅₀: 0.85 nM

Trk2, IC₅₀: 4.6 nM

Trk3, IC₅₀: 0.93 nM

TrkA, IC₅₀: 2 nM

TrkB, IC₅₀: 8 nM

TrkA

TrkB

TrkA

TrkA, IC₅₀: 407 nM

TrkA

TrkA, IC₅₀: 1.9 nM (in cell-based assays)

TrkB, IC₅₀: 2.6 nM (in cell-based assays)

TrkC, IC₅₀: 1.1 nM (in cell-based assays)

TRK

TrkA, IC₅₀: 99 nM

TrkB, IC₅₀: 81 μM

TrkC, IC₅₀: 25 μM

TrkA

TrkA, IC₅₀: 22.4 nM

TrkB

TRK

TrkA, IC₅₀: 7.7 nM (in cell-based assays)

TrkB, IC₅₀: 15 nM (in cell-based assays)

TrkC, IC₅₀: 3.9 nM (in cell-based assays)

TrkA, IC₅₀: 5 nM

TrkB, IC₅₀: 9 nM

TrkA, IC₅₀: 2.4 nM

TrkC, IC₅₀: 0.2 nM

TrkA, IC₅₀: 23.6 nM

TrkA, IC₅₀: 10.5 nM

TrkB, IC₅₀: 0.7 nM

TrkC, IC₅₀: 2.6 nM

TrkA, IC₅₀: 3.3 nM

TrkB, IC₅₀: 6.4 nM

TrkC, IC₅₀: 4.3 nM

TrkA, IC₅₀: 2.74 μM

TrkA

TrkA

TrkC

TrkB

TrkA

TrkA, IC₅₀: 2.9 nM

TrkA

TrkA

TrkC

TrkA

TrkA, IC₅₀: 28.5 nM

TrkA, IC₅₀: 0.33 μM

TrkA, IC₅₀: 1.6 nM

TrkB, IC₅₀: 2.9 nM

TrkC, IC₅₀: 2.0 nM

TrkA, IC₅₀: 2 nM

TrkB, IC₅₀: 3 nM

TrkC, IC₅₀: 2 nM

TrkA, IC₅₀: 1.8 nM

TrkB

TrkA, IC₅₀: 1.8 nM

TrkA, IC₅₀: 0.5 nM
TRKA^G595R, IC₅₀: 14 nM
TRKA^F589L, IC₅₀: 4.4 nM
TRKA^G667C, IC₅₀: 4.8 nM

TrkC, IC₅₀: 9 nM

TrkA, IC₅₀: <25 nM

TrkB, IC₅₀: <5 nM

TrkC, IC₅₀: <25 nM

TrkA

TrkB

TrkA

TrkA, IC₅₀: 8.4 nM (in cell-based assays)

TrkB, IC₅₀: 6.2 nM (in cell-based assays)

TrkC, IC₅₀: 2.2 nM (in cell-based assays)